Probably no help to you, but I had similar issues in fall with Sonar & MOTU. Back then I contacted both companies: Cakewalk, well actually Noel himself, replied that they would help but they have no MOTU rigs in house, hence cannot follow-up. MOTU eventually provided a much better driver, so the issue has gone here ...
However, since you are now getting something similar with RME, which seems to be Cakewalk's number 1 interface for testing, you should have a fair chance that they can reproduce your issues ...
My suggestion would be to see if you can reproduce that after a reboot and possibly also with a new project. If so, get Cakewalk involved. I wouldn't be surprised if Noel himself gets on the case as something like this is either very deep in the audio engine or in the audio driver (which with RME is let's say a lot less likely than with any opther company).
Afterwards I would try to rollback and give it another try, should be quick. Also, what's the status with win10 updates? Are you current or some months behind?