With the ER 2017.2 (UD1 and UD2) there is an issue with the loading of some previous track templates of simple instruments not honouring the original MIDI port assignments of that track template.
When this particular issue manifests, the simple instrument track will be silent because the MIDI component of the simple instrument is remapped to the first available Hardware MIDI port rather than the VSTi, silencing that track.
The bakers are looking into this as we speak.