I think its really helpful working with mono. And it is not about what the final listeners are listening on so much either although that can still be a factor.
When you mix in mono think of all the parts lining up behind each other in a single speaker. Say if you had three rhythm guitars playing and they were all very similar in sound then in mono this would every obvious. Panning will help separate things but mono won't. So you get in there and either edit some of the parts or drop things out or make better choices in the three sounds in order to separate them more.
A mix that starts out sounding good in mono always sounds better after panning in stereo. Compared to a mix that starts out in stereo and collapses rather poorly in mono which many will if you are not careful.
Things that don't collapse well such as some effects and even some synth patches for example can usually be fixed. Often by inverting the phase on one channel before mono is applied. What happens then is in stereo the effects are still there and the synth patches are still wide but they will sound better and usually more robust and often louder too meaning you can turn them down. Then after collapsing to mono you will find those effects and synth patches won't disappear at all but remind behind and still sound good. I think anything that is effected severely by mono test should be looked into.
Panning is another thing as well. Sounds that are panned wide often will drop in level slightly in mono. But what you can do here is just tweak them to be audible nicely again in mono and you will find out wide in stereo they have not changed much. You are now getting things to satisfy two speaker setups rather than just one alone.
Personally I don't like hearing mono from two speakers. There will always be some stereo effect present simply by the fact of your acoustics etc..I prefer a
single type Auratone type speaker and I feed a L+R mix into it all the time and at lower volume too. That way it is just a simple matter to hear it when you need to. The small speaker concept also solves a host of other issues such as critical balance.