I don't know if the stated recommendation by RME to enable MMCSS only when using Cubase/Nuendo is still valid, but at least they didn't remove that passage from the manuals of their recent interfaces.
But it could be an oversight (many aspects in the manuals are shared across multiple interfaces and have not been changed in years -
maybe because there is no need to change...)
I can only speak about my own experience and I never had any problems with MMCSS disabled.
SONAR (still on 2016.10) runs so well without a glitch I don't feel the need to enable MMCSS - well, a test wouldn't hurt but sometimes I'm really lazy...and just keep what works.