I use Macrium free but I don't do regular backups. I copy my project files to external USB drives any time I have something new done. And, although I have now some sample libraries (from Komplete f.i.) they are recent acquisitions and I never installed most of them yet.
I used to save image files of my (whole) system drive but I stopped doing this regularly because I believed that the licenses and activations would not be saved properly this way, and this would be the main reason for imaging a system drive IMO. I mean... OK... it's a pain in the b**t having to reinstall everything but it's not the end of the world. Losing any licenses...well... this raises the problem to another level.
Having said this, coincidentally,
last weekend my c: drive crashed!!!... and I kept most of my software activations there. I restored an old image I made, more than a year ago, into a new SSD drive recently installed (and still mostly empty) and what was my surprise when I saw that many of my licenses where still active!!! All my Waves activations, for instance, even for plugins that I bought some days ago!!! (I had to run windows update to reinstall the latest control center and it took a while, but not a big deal). Also my Arturia plugs where all activated. Of course the plugins are not installed... but the activations are there somehow. I don't know how this works... maybe there is some redundancy in the registration/activation system and the related files are copied in multiple places. Anyway, I'm glad the problem is not as big as I thought at first.
I had no time yet to check all my activations (I have a lot). I reinstalled the latest Sonar release and activated it without problems. I'll take notes about what apps loose the activation and I can report it later if any one is interested.
And I DEFINITELY will start doing regular imaging on my system drive again.