Doc, we've been around and around on this.
For a very niche/specific application, it makes good sense (if you can afford it) to build a machine specific to that particular task. You take away variables from a "general-purpose" scenario... that would result in compromises for a DAW (noise, lower than maximum possible performance, etc).
Again, if you can afford it (not that much more expensive), why live with significant compromises?
In the case of running Kontakt, yes... you could go in and disable Convolution reverbs on every instrument.
You can also freeze all virtual instruments... and all EFX/processing to all audio tracks.
That type of project would run fine on a 500MHz machine. These are compromises we made 10 years ago.
Lucky for us, with today's speed/technology, we don't have to live with those compromises.
With the right machine, you can run these types of projects in realtime... at low ASIO buffer sizes.
We've got numerous hard-core composers taking this example to the extreme (off the top of my head - Sean Beason, Mike Worth, Evan Jolly, and Joseph Briggs). Sean is probably the most extreme composer I've encountered. He's regularly pulling 2000+ simultaneous notes of disk-streaming polyphony.
Sean is doing this in real-time under tight deadlines. There's no time for major workarounds or other impediments that kill work-flow. There's no way any off-the-shelf machine would meet Sean's needs.
While most end-users don't need a machine like Sean's, they benefit from not having to implement work-arounds.
When you've got a great idea in your head... and you're ready to lay down that take, do you really want to switch focus to turning off convolution reverbs, freezing tracks, etc?
It doesn't cost that much more to have a zero compromise machine.
Over the life of the machine... the cost difference is nothing.
Regarding the HP Z series:
It's important to know that Xeon CPUs bring no benefit for DAW use.
They run at significantly slower clock-speed.
Note: Dual CPU motherboards often have issues with audio hardware (audio interfaces, UAD cards, etc).
For corporate server... sure.
For DAW, you can do significantly better at substantially lower cost.