after debating over the Mk4 vs a Presonus 192M with a price reduction, I just ordered the Mk4. I've had a Focusrite Pro24 FW for many years, and I hope the MOTU will last for many more. Figured if I upgrade my mobo in the next year (it's 4 yrs old... is that too old?), I can use the USB since firewire seems to be an outdated concept.
After 2 days using the mk4, I'm loving it. Music seems cleaner with more fidelity... hard to explain but kind of like listening to a low quality mp3@128kb vs the wave file. I heard things on songs I've never noticed before. I was thinking about upgrading monitors but I'm good for now.
The matrix will take some getting used to, but I like the dsp where I can run inputs thru the motu mixer. It works fine w the latest Win 10 for me, and no probs w SPLAT. Knock on wood, hope this works for years like my other equip.