I turned off all windows sounds, and still the problem persists.
Soundforge will switch to whatever sample bit-depth or playback rate of the source, but it always starts up at 44.1kHz, so I get that little click on every sample rate change. The Saffire Mixcontrol is locked at 44.1kHz when this happens, but when I close Soundforge it goes back to 48kHz.
I'll live with that and hope Magix is working on a newer version.
@jimkleban - Soundforge will not allow me to change the audio settings when I choose the Saffire driver setting which makes it load its internal ASIO driver - it always insists on 44.1kHz, even though the Windows sound control panel is 48kHz. Somehow it locks the interface to that initially, but will adjust to the sample rate of the file it plays back as needed.
Maybe it is something to do with Firewire. That was always flakey with 32-bit apps.