With a custom machine, you have complete control over what goes in... and exactly how it's configured.
Choose top-tier components for each... and configure it well... and you'll have a machine that's superior to an off-the-shelf machine. You won't get that attention to detail (DAW performance) in a general-purpose solution.
- Case (quiet/robust)
- Motherboard (quality unit with proper parameters for super low/consistent DPC Latency)
- HDs or SSDs (fast quiet units)
- Power-supply (robust quiet unit)
- CPU cooler (over-spec'd large/quiet unit)
- OS Install (clean/lean - no "value added" bloat)
The higher your performance expectations, the more significant the difference
Whether you need that level of performance... that's a question only you can answer.