MOST power conditioners are like any other after-market add-on, very high margin products that don't often really do anything.
Step 1 - do you have a power problem?
Step 2 - what is your power problem? High or Low voltage, insufficient current, noise, transients, frequent outages, or what?
Step 3 - select the appropriate device to resolve your problem or problems.
The only blanket caveats I am comfortable with include:
- you should avoid devices that use MOVs to shunt noise to ground. They are not a good idea around computers or other sensitive devices. If you have a problem with spikes you want series mode protection devices, SurgeX and Middle Atlantic both offer them. They absorb the spike instead of just dumping it to ground.
- Avoid ALL schemes that involve separate ground rods. They don't work, they are way too expensive, and if done poorly they can create a dangerous ground potential difference.
If you have noise problems consider an isolation transformer, and if that is not sufficient consider a "separately derived" sub-panel, fed from an isolation transformer. It is equally important to choose a grounding system that is appropriate - the two main categories are single-point and mesh, both work, and they can be combined, but that is some tricky business!
TL:DR - most power conditioners are snake oil, get one only if you know (a) what you are solving, and (b) that it will solve that specific problem!