Hey Bruce. Actually I just used a 335 through an old Vamp 2 for everything using the Mesa Boogie Mark II C setting. It's called "California Clean" on the unit. I had both the volume and tone rolled about halfway back on the guitar probably. I don't think I used any compression.
If you're using a guitar with single coils I can tell you that my Telecaster sounds much better through the "Modern Class A" setting. (It's supposed to be based on a Matchless Chieftain.) I usually hit it with compression using the Tele, especially if I'm playing clean, and I boost the the highs on my cheap Behringer XENYX H1622 mixing desk at 3Khz, mids at 500hz, and the lows at 60hz. I just run the 1/4" outputs to the 1/4" inputs of a 15-year old Echo MIA Midi sound card.
I always use the single 12" open back cab setting for everything.
You can pickup used Vamp 2 units for $30 or $40 all day long.
Anyway, that's all I do. It's a very inexpensive way to go that sounds pretty darn good in my opinion.
Thanks for asking. Good luck!
Bill