A brief update
Tried using Melodyne as an FX insert not Region FX.
Inserted, it opened ok and processed OK - all was great until I tired to freeze track, then it crashed - after the crash the project would not open until Melodyne removed.
Whilst clearly a Melodyne issue, I think someone at Cakewalk / Gibson should be shaking a VERY big stick at Melodyne to get things sorted!!
By the way, anyone know if Melodyne is such an issue in other programs with ARA integration - I believe Studio One has this??
Nigel