I consistently experience the crash described in this thread. On my current project, Sonar crashes whenever I create a new Region FX with Melodyne 4.00.0401. I'm running Windows 10 with 64 bit plugins end to end. I've been in touch with Celemony and sent them a minidump file on 3/24/2016, but no response yet. (A few days before, they promptly responded to a license problem I had. Turned out to be user error trying to fall back to Essentials 2.)
I never had a problem with Melodyne Essentials 2. I upgraded to 4, then used the temporary demo license for Editor, then fell back to Essentials. I didn't use the system for several weeks after that, and when I resumed, the crashes started. Existing Melodyne Region FX work fine, and I can open and edit them--I just can't create a new region.
Oh, and to add insult to injury, somewhere along the line, all my edits to Melodyne regions were lost. The regions still existed, but all pitch and time corrections vanished, and I had to reapply them.