After a dozen reboots today XD, nah nothing else accessing my audio. One of the first things I did was disable stuff like discord from starting up on boot. 
I'm using the tascam for all audio and everything except sonar works. All audio goes out fine, the mic plugged into the unit runs fine. 
I'll try disabling everything under sound in device manager, reboot and see what happens (fingers crossed for some magic).
 

(USB 2.0, found on nearly any computer, is used as the interface for the US-2x2. Simply connect the interface to any available USB port to supply plenty of bandwidth, even for multichannel 96k work. (The US-2x2 and US-4x4 are also compatible with USB 3.0 ports.))
 

Jesse G
The Tascam USB 2X2 is USB 2.0 ONLY !!!  I believe trying to connect it to a USB 3.0 Port is the the problem.
 
The specs sheet for the Tascam US-2X2 refers to it as a USB 2.0 device only, see the SPECS SHEET
Compatible computers Windows-compatible computer with a USB 2.0 port
 
Windows
 OSWindows 7(32-bit SP1, 64-bit SP1), Windows 8.0(32-bit, 64-bit), Windows 8.1(32-bit, 64-bit)

* For further information of the latest OS version, please click here.Compatible computersWindows-compatible computer with a USB 2.0 port  CPU type/speedDual core/2 GHz or faster (x86)Memory2GB or moreDRIVERASIO2.0, WDM(MME)

Good point.  Some USB3 implementations work fine with USB2 devices, others don't so it's hit/miss.
 
OTOH, the OP's other software and Windows itself don't seem to have problems.  It might be worth uninstalling LE and trying one of the current demos

I hate to say it but this is also the possibility that SONAR LE simply sucks. I've never used it so I don't know for sure. I also haven't heard anything about LE being updated any time recently.
 
And honestly, it seems whenever someone posts an LE thread the result is never a happy resolution.
 
So yeah... it could just be LE is buggin' out. The paid versions work well at the moment.

What about updating the firmware, has that been done?
 

I did get a key for ableton live as well as sonar le. 
I am contemplating trying to install it all on my laptop but I'm not sure if the voltage from the usb is enough for the 48V output.

Install Ableton Live and try to configure it with the ASIO driver and if it works OK it will prove the interface is running correctly.  

Its a brand new unit, this is my 2nd one. I've had it 2 days. Firmware version 1.01. which is the latest version.
My first unit I sent back as it wouldn't work until I unplugged it and plugged it back in after every boot.
 
I'll try ableton

It won't hurt to get a USB 2.0 PCI or PCI-e and add ad it. the Tascam US-2x2 goes back to 2014
 

IDK about configuring ableton with ASIO, as I say this is all new. I installed it and it auto loaded a demo, I hit play and it works. Not sure if I need to change something or not.
 
As for buying a USB 2.0 card. IDK if I really need it. It wouldn't hurt but if I dont need it (which I shouldn't) its just an extra expense.