I've upgraded my DAW Desktop, laptop, and living room computers to Windows 10 Pro.
I had no serious issues doing the upgrade except for some mis-adventures in converting to a Microsoft Account from a Local Account. That conversion resulted in some permissions problems for User locations that were moved with the 'Locate' setting to other drives. For simplicity, I would not alter the accounts, but rather create a new account using the MS Account (for Cortona, OneDrive, etc.).
On my DAW I'm using the beta Focusrite Saffire Pro 14 Mixcontrol 3.61b1.
On my laptop, a motherboard Realtek interface and the Focusrite Scarlett SOLO USB version 3.1.10.221.
On my living room computer I stream audio through HDMI to my TV.
I Run Sonar Platinum on my DAW and Laptop. On the Living room I have Sonar X3 installed.
I've been at this round-the-clock for the last few days and I'm happy with my settings and results.
I'm doing backups as I write this and settling down for some computer rest and rehab.
EDIT:
Some advice on upgrading.
I would not upgrade using the 'Express' settings - that changes a lot of default applications (Bing, Edge, Cortana, etc.).
Use the Custom settings and look at each one carefully. I want to keep my Chrome browser.
After the upgrade, look at the settings for Windows Update and choose: Notify to schedule restarts.
Also decline to use the peer-to-peer update delivery.
I tried to set up a Homegroup among these three computers, but that did not work out very well - I just use Folder Sharing for a few public locations. It's probably because I have used 'Locate' to move my User folders to various drives. It tends to give 'HomeUser' access rights instead of my account access rights, so I have to save as administrator onto my documents folder.
I ended up disabling all the Homegroup nonsense and modifying Security settings on my User folders. Lots of fun time wasted on that.
Most users that have a single drive and just a Microsoft account will probably do fine, just be careful when things get complicated.