I'm running Win10 and a Focusrite 18i20. Installed the new beta mixcontrol software and beta driver but the audio is poor quality and full of clicks. No amount of tweaking works. I've had to uninstall them and put the old software and driver back, which is working fine with win10. I have tried 3 times to get it to work, always the same result. Kudo's to Focusrite for moving quickly, but a gong for now...

Mine is running great on Win 10 x 64 - it feels a bit more solid than Win 7. RME all the way..

According to Focusrite
 
We have become aware of a connectivity issue running Saffire units on Windows 10 connected to firewire cards with a VIA chipset. We are currently investigating this issue as a top priority. In the meantime, if you are using a VIA chipset, we recommend you do not update to Windows 10. 
 
This directly effects me, and I've confirmed it, so no go for me.

I will say the slowness of pro audio companies in this regard has always been an annoyance of mine. New OS comes out and they hem and haw and drag their feet on getting support for it. It again makes me think about RME for an interface since they were quick to declare support for their drivers on Windows 10.
 
I have a Focusrite card and the "Oh just use the beta drivers" rather annoys me. Guys, there has been a lot of time to test this. It isn't like MS sneaks their OS updates out, they have lots and lots of beta time to develop their stuff. Get on the stick :P.
 
At this point it is what I'm waiting on to upgrade my desktop. The rest of my hardware has Windows 10 certified drivers (often the same as the 8.1 drivers, but they've tested and certified them) Cakewalk and NI say their stuff is good to go with Windows 10. However Focusrite says you need to use their beta driver and I'm not really interested in that, so I wait for now.

Sycraft
At this point it is what I'm waiting on to upgrade my desktop. The rest of my hardware has Windows 10 certified drivers (often the same as the 8.1 drivers, but they've tested and certified them) Cakewalk and NI say their stuff is good to go with Windows 10. However Focusrite says you need to use their beta driver and I'm not really interested in that, so I wait for now.

That's because Focusrite is probably spending more time than most companies testing their gear. I've used their betas in the past and they've always been better. Focusrite beta software is probably the only beta software I would willingly put on my environment.

Personally I'll wait, particularly since there's no need to upgrade at this point. I just always get a little annoyed with pro audio companies and the amount of time it takes them on drivers. nVidia had drivers out day 1 which were WHQL certified and supported DirectX 12. That is a massive amount of work (graphics drivers these days are exceedingly complex) yet they were able to do it and indeed had drivers during the beta.
 
However pro audio companies always drag on this stuff. Except for RME. That, combined with the fact that they still support their old stuff and their nice mixer makes me really, really look hard at their interfaces.

Sycraft
Personally I'll wait, particularly since there's no need to upgrade at this point. I just always get a little annoyed with pro audio companies and the amount of time it takes them on drivers. nVidia had drivers out day 1 which were WHQL certified and supported DirectX 12. That is a massive amount of work (graphics drivers these days are exceedingly complex) yet they were able to do it and indeed had drivers during the beta.

 
And look what happened:
http://www.theregister.co.uk/2015/07/28/windows_10_update_nvidia_driver_conflict/
 
... think they were in too much of a rush  They clearly didn't test it very well ...
And don't forget nvidia is a gazillion dollar company with shed loads of resources...
Also noticing the nvidia drivers supplied with Win 10 are seriously crappy (most makes/models), it's always best to download latest from their site afterwards.
 

I'm using Native Instruments Komplete Audio 6 interface and it works just fine. I've had no issues with Windows 10.
Splat seems to move through the OS seamlessly.
But with that said, I'm waiting to upgrade my 1tb HD Acer Laptop to Windows 10 and that will be my final call and verdict for Windows...

ancient edirol ua-1000 working fine with vista drivers :-)

Susan G
Hi Max-
 
...I'm sort of in the same boat with my Komplete Audio 6. The NI web site suggests holding off on Windows 10 until they've completed compatibility tests with the release version.
 

Bummer. I have the same interface.
 
NI has a new driver for KA6, v4.2.0. Have you had a chance to try it out to see if it works? 
 
Though I doubt it officially supports W10, I'll try it later on my W10 laptop.