Own a 896mk3 Hybrid (am using USB2.0) for routing. Am using it at its lowest setting 64 spls 2.7/3.3ms with np. It has a built in hardware mixer (via CueMix [no latency]) that allows you to mix in all 32 inputs into 8 stereo busses and can be used stand-alone.
I'm really enjoying mine and using it to get audio (mostly stereo) out of my PC and into my VS-2480 (another hardware unit [no latency]) and back into my DAW.
Own an FA-08 that I use to convert all midi to .wav and load into my DAW for quality mixing while mastering is done in the Roland VS-2480. Also own a a JV-1010, Axon Terratec Producer, DigiTech GSP1101, VoiceLive Rack which I use for Vocals and Instruments, and a Casio WK-3700, and Korg Triton-Le.
Since I've gotten my Roland FA-08 I haven't been using the JV-1010, Axon, nor the Casio/Korg keyboards. I still use my MOTU MTP/AV (Timepiece), but no longer using it for midi, just synchronization.
However, since the Pre's are better on the 896mk3 than the VS-2480, and the mixer is better than my Behringer EuroRack, I now use the MOTU 896mk3 for all of my routing/mixing and it is working quite well for me.