Your computer motherboard has a built-in Nahimic, Audio3 audio circuit which has gold plated audio connectors, EMI shielded audio processor, audio circuit isolated from the rest of the motherboard, audio quality capacitors, dual headphone amplifiers that support both low and high impedance headphones and there is physical support for both rear and front case headphone jacks. All of that bodes well for obtaining and producing acceptable audio quality.
Potential areas of concern:
Does the audio circuit designer, Nahimic, provide standalone audio drivers (good to excellent idea) or is the audio drivers embedded in the included Nahimic Audio3 software package (potentially bad). While the software package maybe great it includes MANY features you don't want such as virtual surround, bass boost, voice leveler, noise gate and reduction and voice clarifies. If you don't have some way of turning off these features they will interfere with your mission.
Does the motherboard have a discrete, separate power connector just for the audio circuit? Power supplies deteriorate with use and over time. The power supply can transmit electrical noise from another part of the computer to the audio circuit. There is a reduced chance of this happening when the audio circuit has its own input power connection.
Depending on how you listen headphones, powered speakers or both you may need to use "Y" cables and 3.5mm to 1/4" adapters. Adapters deteriorate over time without maintenance and could become the weakest chain in your system.
I'm really glad you asked this question. I have been investigating the motherboard as audio interface for awhile so it gave me an opportunity to voice some of my concerns.
I believe you will be happy with your setup.