JD - if you happen to browse the zillions of posts in here about this topic,  you'll definitely and frequently come across the mention of Focusrite products.  I want to put in a good word for them.
 
1. Good options. Low latency.
2. Excellent, clean pre-amps.
3. Offerings to fit low budget as well as expanded budget
4. Good software interface that accompanies the hardware. That means, easy to use (compared to others).
5. Good reputation - drivers work, plug and play, typically people find the products great and don't complain
Bonus round:
6. Focusrite has a thing called the Focusrite VRM Box (you don't need a Focusrite audio interface to use it, but you do need SPDIF outputs - which Focusrite audio interfaces often have except for the lowest end ones).  The Focusrite VRM Box is a low cost item and can really help with mixing if you use headphones for at all or some of your mixing.

I cancelled my Presonus 44VSL order and have now gone with the new Steinberg UR-44.  It has 6 in/6 out and can interface with Windows, Mac and iPad.  
Very clean mic pres and zero latency monitoring software.  Initial reviews have been really good.  
I will post a review after I get it in about 2 weeks.
 
Rimshot
 

@Rimshot: Curious to see what your roundtrip latency will give you. I have a top-noth DAW PC but now the UR-44 is the culprit giving me only <10ms on 44.1KHz/64 buffer while more conventional settings such as 44/128 give me close to 14 ms. It might be enough for you but I need <10ms so already thinking about selling for an RME. Will cost me probably since I also need 4 mic inputs :(
 
@lawajava: The VRM Box can easily be attached to your PC through USB as a separate interface. Only workaround is that when you want to start mixing and referencing on cans you need to manually select is as an audio output.
There is one reasonibly priced Focusrite model that comes with the VRM tech as well. More expensive than other options mentioned here (aside from RME) but all-in-one since essentially it's the VRM Software that does the processing and not the VRM Box.
 
 
 

I have a Focusrite 2i2, which is more than fine, but I just dropped some dough on a Line 6 UX2, if for nothing else than Pod Farm and the cool VU meters! I will see if I can see a diff in the preamp quality when it arrives. The only real issue I have with the 2i2 is it is so small and light it moves around and I have to hold it when plugging stuff in and out. I could get that 1/4 cable with the mute switch on it.....hmmm. I'm afraid of it doing something to the signal, but who knows?
 
I have had a few Focusrite products and you can never go wrong with a Focusrite......I think there's an ad in there somewhere.

this thread is over a year old.
 

batsbrew
this thread is over a year old.
 

So am I

Jim Roseberry
When it comes to low round-trip latency, the distinguishing factor between audio interfaces is the size of its hidden safety-buffer.  The larger the hidden safety-buffer, the larger the round-trip latency.
 
The best audio interfaces yield ~5ms total round-trip latency at a 64-sample ASIO buffer size/44.1k.
The quality of the audio interface's driver is paramount to achieving glitch-free low round-trip latency (while running substantial loads).  Not all drivers are created equal...
RME is particularly good in this regard... as are Lynx and MOTU units.
 
PCIe vs. USB vs. Firewire:
Make a good choice, and you can achieve low round-trip latency with any of the above.
ie: RME USB units achieve total round-trip latency of 4.9ms at a 48-sample ASIO buffer size/44.1k (clean playback running substantial loads)
 
The Steinberg UR-44 is a new (relatively low cost) audio interface that offers good fidelity and low round-trip latency.

 If you have a local Guitar Center these were on sale for $119.
 

kitekrazy1

Jim Roseberry
 
The Steinberg UR-44 is a new (relatively low cost) audio interface that offers good fidelity and low round-trip latency.

 If you have a local Guitar Center these were on sale for $119.

In 2014 ? :o)
Doesn't help today...

Kalle Rantaaho

kitekrazy1

Jim Roseberry
 
The Steinberg UR-44 is a new (relatively low cost) audio interface that offers good fidelity and low round-trip latency.

 If you have a local Guitar Center these were on sale for $119.

In 2014 ? :o)
Doesn't help today...

 $119 went i went into a GC  last Friday, May 29, 2015.

Try the Roland Quad Capture. I have the Octa-Capture and the latency is extremely low.

I used to have problems putting sends on my buses and sending them to another bus which went to outs 3/4 for a headphone mix. The vocalist would always hear a delay in the head phones when singing. This was happening with the Persons FirePod. When I purchased the Octagon Capture, the latency was so low, the problems went a way. Plus it has features that will blow you away.

If you can save up some more money, do it and get an Octagon Capture! If not, the try a Roland Quad Capture.

Peace,

Jesse G.