The Focusrite units can record/playback glitch-free at a 64-sample ASIO buffer size.
Your machine is a big factor in playing back glitch-free.
The load you're trying to run is also a big factor.
Both RME and MOTU offer lower round-trip latency than Focusrite.
That may... or may not be important to you.
If you haven't purchased the audio interface, I'd steer you toward to Ultralite AVB over the 18i8.