I just got hit with the "not loading" problem today. What I find is that everything recognized in Windows and even the MOTU Discover app, but I get no sound anywhere in Windows and something like "No ASIO Device Found" in all my DAW programs.
Power on/off/etc doesn't fix it.
I found that changing the sample rate via the MOTU Discovery app, seems to wake it up.
So if it's at 48k, I change it to 44k, make sure MOTU is default device in Windows, reboot (not sure if this needs to be done) and now it's fine.
Weird bug because it doesn't happen all the time.