I've been building my own PC (and for others) for quite some time, at least since XP days.
It keeps getting easier.
You should do your homework, for example, checking Tom's Hardware guides for motherboards and some of the overclocking sites.
I would get the fastest possible motherboard PCI lanes, memory chips and unlocked CPU. Use water cooling and a good power supply.
Gets lots of memory, at least 16 GB or more.
I use some really power hungry VSTs (Reaktor, in particular), I run at 4.3 GHz and wish I had more.