For what it's worth,
I run
1 x 2 TB Seagate SSHD hybrid for my OS, no partition.
1 x 2 TB Seagate SSHD hybrid for my audio, no partition.
I can get 150 tracks at 48k 24bit with about 3 plugins per track plus Prochannel, x2 oversampling and 64x internal, 20+ busses running Ozone, Multibands, side-chains etc, plus a video playing back on the onboard graphics card. All of that on a 6-year old i7 2600 intel with 16GB DDR3 RAM.
I doubt partitions would get me any better performance than that! :O)