I have it on all my PCs and even my Phone. I love it. I got a new pad on Friday (Asus T100TA) and the first thing i did was installing windows 10. It Works as great as 32bit as 64bit. My pad only har 2 GB or ram and it is not that troublesome. Only thing is that too many internet sides opened at once makes it leggy. But for those not familiar to development of software stay away before the official release. Because for now your on your own regard of safety and failure.
I am looking for the new release coming next week. 10147 or something. This will give a huge amount of bug fixes.

Jarvsve, have they released the full tablet experience yet?

I've just hit this brick wall with my MOTU Traveler.  Windows 10 is amazing and loving it but my audio is bricked for now.
 
Has anyone tried running one with the Firewire legacy drivers?

I stuck it on my laptop and it works very well. Desktop I'm holding off until compatibility testing has been done. At this time NI and Waves both don't have statements on Windows 10. There's no reason they shouldn't work, but I'll wait. Since 8.1 works fine and I don't wanna have issues o my main system, I'm going to wait on official support from Focusrite, NI, and Waves (and Cakewalk but they already have it) just to avoid any problems.
 
I did an upgrade, which worked fine, because I wanted to see how well it'd go. The desktop will be a fresh install.
 
AMD has drivers and they work as well as AMD drivers ever do. They have Enduro (laptop switchable graphics) issues in that they don't shut off the dGPU but they seem to work fine and don't crash.

JClosed
I do not doubt that, but -as I said- I have an Saffire (the white/silver model).

What is the exact model?

I didn't do a thing to my system and yesterday the MOTU Traveler just started working!  All good here, the upgrade went really well.

charlyg
I upgraded, and then cloned it to an SSD. It wouldn't install straight to an SSD....I am liking it more every day....... My install of 8 was new (computer upgrade and bogus Win7 license), and for some reason, I couldn't get 8.1 to install (some weird issue), so I just jumped ahead...and I'm glad I did.

I did my upgrade direct to my SSD without issue....just an FYI