What are using for a soundcard ?
I did have an issue like this recently and for me it turned out to be my Anti virus.
It was so bad I could literally hear my I7 crying it was winding so hard.
my best guess is the plug ins were throwing off a PUP warning and my AV was scanning it each time.
but it didn't show up in TM. so I had no idea what it was.
I added an exception for Sonars plug in folder locations, the Plug in scanner, the EXE...everything I could think of and the next time I re booted my PC it was gone. absolutely fine.
You might be able to go through one by one and load each plug in seeing if its one plug in that is the offender.
Open Sonar in safe mode (Hold down SHIFT while opening Sonar).
This might help you narrow down if one plug in is the offender. I wouldn't even think RAM has anything to do with it.
I load a ton of SS and sometimes have 50+ tracks loaded with plug ins and im only using 16GB of RAM.