Hi,
I have a project that I've been working on, off and on, for a couple years now. I'm using Platinum, and it's a mixture of about 50 tracks, with a mix of audio and plugin based tracks. Up until a couple months ago, everything was fine. But now whenever I play back, certain midi notes are skipped, i.e. not played. I eventually figured out if I disable the plugins (hit the FX button), all the notes play. But if I export the audio, everything is there as it should be. I have a reasonably powerful 8-core, 16GB ram machine (I've managed projects more than 100 tracks). The CPU and ram meters never get really high - in fact they've gotten a lot higher in the past than what they are now. It even does it if I solo a single track.
I've messed with the Playback and Recording settings (multiprocessing engine, plugin load balancing, share drivers with other programs, MMCSS, etc...) and nothing seems to make a difference.
My audio interface is a pair of Focusrite Saffire Pro40s, running in ASIO mode, AMD FX8150, 16GB ram, SSD boot drive, 7200rpm Audio drive.
One thing to note, this seems to be the only project I'm having problems with.