.

On motherboards prior to the Z77 chipset, literally *all* USB-3 controllers were 3rd-party.
USB-3 had not yet been integrated into the Intel chipset.
 
Using a 3rd-party USB-3 controller can indeed cause issues with many USB audio interfaces and MIDI controllers.
We've seen it countless times...
 
If you're running a Z77, Z87, Z97, Z170, Z170x, X99, or X99p motherboard (or derivatives), you're fine as USB-3 is integrated into the Intel chipset.
 
You implied correctly.  
The USB controller can/does make a difference.
If you've got an older motherboard with 3rd-party USB-3 controller, the solution is to use the USB-2 ports (which are Intel).  There's no performance advantage when connecting a USB-2 audio interface to a USB-3 port.
 
This is no different than talking about using a Firewire audio interface.
For maximum performance and compatibility, you want to use a TI chipset Firewire controller.
 
Same with SATA-III controllers...
Connect a current generation SSD to a 3rd-party SATA-III controller... and benchmark it.
Now, connect that same SSD to an Intel SATA-III port... and benchmark it.
In most cases, you'll find that the Intel SATA-III controller outperforms the 3rd-party controller.
 

Jim Roseberry
Lynx makes excellent audio interfaces.
I used an AES-16e-50 (AES-50 port) for a while... connected to an X32.
Rock solid performance with DAW software... and you can take the ASIO buffer size down to 32-samples.
 
If you plan to use an older PCI Lynx card, they don't work well in bridged PCI slots.
Any current generation motherboard with PCI slots is using a bridge chip.
 

I can't find any information on this.  People complain that using pci-pcie adapter cards are a no go.  But I can't find anything on *bridged pci slots with the Lynx L22.*

I borrow this thread for a moment:
 
I have a Focusrite Saffire 6 USB since 4 years and it has earlier worked fine except for a little too high latency when there is plenty of tracks. Lately I have been using more of the Eastwest Play plugin (Hollywood orch platinum). I get really high latency and the performance is like the notes are "stumbling". If I try to play 16th+ 16th+ a 4th, the result can be randomly like 32th, dotted 16th or vice versa. And the stumbling remains at playback, which makes the plugin sort of unworkable.
 
So... I have glanced at the old RME Fireface UC that I can get for what I think a fair price. Would an interface like this solve the latency and stumbling, or is it a common result of EW Play? I don't think the problem is my computer (see tech below), though it is 4-5 years old.
 
Edit: I have SONAR Platinum now

eph221
 
I can't find any information on this.  People complain that using pci-pcie adapter cards are a no go.  But I can't find anything on *bridged pci slots with the Lynx L22.*

FWIW, We've never seen a Lynx PCI audio interface work properly in a bridged PCI slot.
This is based on numerous scenarios... with numerous different makes/models of motherboard.
Echo tended to work with certain bridge chips, RME and M-Audio worked without issues.
 
Avoid Lynx PCI units on any current generation machine... as all PCI slots are bridged.
 
 

It's working fine for me with a buffer of 32, but if something starts creeping up I'll know.  Thanks for the advice.

If you've got an X79 motherboard, it has true PCI slot/s (not bridged).

In addition to x79 the B75, Q75, and Q77 use conventional pci (non bridged).  I have a Q77.  At least that's what their spec sheet says.  According to intel third party manufacturers use the bridged chipsets *sometimes*.

Don't go for a Z77, Z87, Z97, H97, Z170, Z170x, or X99 motherboard.  
 
At this point, it's hard to find Z77 motherboards... let alone the derivatives.
Z87 derivatives are also hard to find.
If you can find one, is most likely going to be Micro ATX form factor.
 
If you're talking about a new build (Z97, H97, Z170, Z170x), if the motherboard has a PCI slot, it's bridged.
You can look at the motherboard's layout chart in the manual.  The bridge chip is typically near the PCI slot/s.  
Gigabyte and ASRock clearly identify the bridge chip.  Asus gives the chip name (which you can lookup).
 
We've never seen a Lynx PCI audio interface work properly in *any* bridged PCI slot.
 
This isn't to slag Lynx.  
I used a PCIe Lynx AES-16e-50 (AES-16e with AES-50 port) as my main audio interface when using an X32.
Excellent performance in DAW applications...

Do you have  your EastWest sample libraries on a separate drive from your projects and Sonar?