Sometimes these issues can be really trivial. as JB mentioned, could be existing distortion, Could also be that you unplugged everything from your PC to work on the computer (to install the new video card) and now something is either - plugged in the wrong port, not plugged in correctly, a loose wire.
When you tried to upgrade your new video card, did you remove / try and update any drivers ?
can be so many things. I would start by going through the basics.
-Make sure the M audio sound card is plugged in to the same port you installed the driver to.
-Don't plug a USB 2 device in to a USB 3 port.