With modern disks, what is installed is not a big problem.
The real problem with modern OSes (except Linux) is what OS can decide to run unattended. I mean the TaskManager and Services. Tasks and Services can be disabled, but I have not found a good tool for "one button" disable/enable everything (not essential for the DAW).
Services are not so bad (as long as updates and security scans are disables), but the Task Manager drives me crazy. It wants to run 100s (!) of tasks, some can be seen as "planned" but most are triggered by "idle" or something different. I would like to just kill the task manager, but Win10 fights against that operation and I have not found a workaround (yet).
Many tasks are quite resource hungry (disk checks, telemetry, etc.). On my notebook such tasks periodically produce "clicks and pops" with low ASIO buffer. Latency checker does not report and bad driver, RME does not report dropped packets and overall system load is small. But still happens. Till now with "online" only, but I can imagine that can happened in offline environment as well.