I am working my way thru prochannel (for the 1st time).  In the past, w/o PC, I didn't have any trouble routing thru various buses then to the master w/boost 11.  Now it appears as an off shade color in the bus - not grayed out, but dingy yellow and no signal is getting to it.   What am I missing?

The plug maybe by-passed - place your mouse in the block next to the plug name and see if the switch is greyed out - if so select it to activate. I have heard that there might be a future update where the GUI is more configurable ?- I'm hoping that the plug-in enable switches can be exchanged with the pre-post switches so they are always visible at a glance.

It has a power switch dead center between the knobs. make sure it's powered on!

Check that the FX Bin is turned on.

On your transport, the bar that goes along the top of the screen, there is one section that has an "M", an "S", and a red dot.  If any of those are lit up, then something is Mute, or Solo-ed, or armed for recording.
 
In the second row below those 3, is a button labeled "FX".  If that button is lit, then all plugins are disabled including Boost.  [I've lost track of the number of times that something refused to work, when all along it was the FX button.]

Yeah, that little fx switch at the bottom catches me all the time.  Have to check that and make sure it isn't cancelling out your vsts.  Amazing how that little switch can change your sound. hahaha