I've used Acronis since probably 2008 or earlier. Some releases were troublesome, but fixes eventually appeared.
I find ATI 2015 to be a big improvement and simplification. The PE boot creation is now completely automated, like Macrium. I recommend either tool, but I prefer Acronis because I know it better.
I also use Retrospect for incremental file backup (nightly), but use Acronis for monthly images (or more frequent) especially before Patch Tuesdays.
I keep the system C drive minimal and backups with verification take about 20 minutes. Restores are a lot quicker then debugging, so I never hesitate to restore when I encounter some sort of software installation or other problem.
I have yet to find an image restoration problem.
I use YUMI
http://www.pendrivelinux.com/yumi-multiboot-usb-creator/ to make FAT32 boot USB drives with ATI WinPE 2015, Acronis Disk Director WinPE 12, a Linux Mint distro, Hiren's Boot CD, and Kaspersky AV disk images and a few other such tools. You can fit a lot of boot ISOs on even a small Flash drive and they boot quite a bit faster than DVDs. You just have to boot in Legacy mode (if you have a UEFI secure boot BIOS) and make sure the boot prom supports USB. I think all modern BIOS products made in the last few years will do that.
Unfortunately, I don't know of any way to make bootable NTFS flash drives or multi-partition flash drives. I prefer NTFS because I like to have encrypted folders on these portable devices for saving passwords, etc. Without the NTFS EFS support I have to use encrypted archives for such stuff.
A flash drive is modelled after the floppy paradigm - a removable media. So it does not support multiple partitions. Apparently there is no way to eject multiple partitions at once in Windows. Or maybe there are other reasons for that lack of functionality.
There was a protocol called U3 developed at Sandisk for some stuff like that, but it was problematic and is no longer supported.
See:
https://en.wikipedia.org/wiki/U3