TH3 should work fine, but I've discovered that, when used as a plugin, hosts sometimes "choke" on it a bit. The reason seems to be that they expose ALL of their parameters for all available amps, cabs, effects etc... regardless of what is currently loaded and used.
So if you just have an amp and a cab - TH3 still provides the host with thousands of parameters. I've asked them to fix this so we'll see if one of the updates does, but this may just be a case of waiting a bit and see if the host catches up. Some hosts seems to handle it (Logic Pro X), but every time the playhead reaches a point where a midi command is sent to TH3 - the entire application freezes for a heartbeat. No impact on audio though.
Seems not to be happening in our plugin host for live performance (Gig Performer), but this should really be addressed by the plugin creators themselves.
Dj,
gigperformer.com
Cross-platform plug-in host for live performances