The most common annoyance for me in this regard is failing to hit Enter or double-click properly before editing a value or text field, and having my typing execute a bunch of commands before I catch it. I'm sure this never happens to anyone else here.
Since most keyboard shortcuts are related to opening/closing panes, changing screensets and toggling things like Looping, Global FX, Aim Assist, Muting, etc. on/off, it's usually not a huge deal, and easy to back out if you just think about what you typed. Hitting numbers that change screensets is immediately obvious, and scary before you realize what happened. I've re-assigned most of those to harmless functions like resetting peak indicators or to the 'Do Nothing' function.
Probably the only one that's potentially destructive is if you have a track armed, and hit R in Overwrite mode, but Undo should take care of that. S for split is another one you might need to Undo, but I've re-mapped it to Set Measure/Beat At Now which doesn't do anything unless you hit Enter after the dialog pops up.