I never have had this problem, use it all the time, and have never checked the DPE box.
So I checked the DPE box and used VS. No problems.
Is this your scenario? You have two vocal tracks, A and B. You use VS to set up a region on B, but you never tell it to reference A, and then hit play? Is that when the explosion happens? If yes, I'd think that explainable by VS trying to match up B to the drums, bass, or nothing at all. When I'm driving and let go of the wheel, I typically crash.