I've been having plenty of Windows 10 issues...
...and I just did the upgrade from Win7 Pro x64 to Win 10 Pro x64 - not a clean install.
Most of the issues are driver related.
Some crashes point to the Universal Audio plugins.
Are the plugins you refer to from UA by chance?
On UA's support site, they are recommending that you do NOT update to Win 10 Anniversary, as
their drivers do not comply with the latest Windows 10 updates...
...go figure.
Would have been nice to know before Microsoft was kind enough to do the update anyway...