Focusrite interfaces offer a superb price:performance ratio, which is why I use one. But one of the reasons they're a great bargain is the chipset they (and many other manufacturers) use, which is cheap (good for consumers) but incapable of the lowest latencies offered by more expensive brands (e.g. RME).
For me, it was a reasonable tradeoff because I don't care about low-latency performance. But if you're someone who plays sampled instruments in real time, and therefore needs to get round-trip latency down under 20 ms, then you're probably looking at a pricey hardware upgrade to achieve that.