Metronome "click track" versus drum track

Need help on why this is happening between my playing along with and getting into the beat of a metronome versus a drum sample track. I am sure that all is sync'd to the project tempo. So in playing an acoustic guitar strum with the metronome, it feels right and I like how it fits. So then, drop and drag in a drum sample and it seems off --- the "groove" supposedly at the same tempo throws me off and my strumming part gets off! I am thinking maybe I am choosing the wrong clip. Perhaps the problem is that the drum clip I chose must be originally recorded at the exact tempo as the project I am now working in? Not sure - please advise.. 
 
Thanks !! 

Is it audio or MIDI?
It may just be the wrong clip for the purpose. As Jeff noted, the groove may not be on the metronome beat.
For instance, I tend like a swing or shuffle, and these have very different feels from a straight metronome.

Maybe try strumming a few bars over the metronome, then create a simple click (kick & hi-hat maybe), quantize that, stretch it out, and dump the metronome. That way you can catch the groove of what you're playing.

My "click" is snare and kick, not even any hihat. I've got a lot of snap in the snare and a lot of click in the kick, and I set them up in the step sequencer with no swing at all. For composition, I need tight timing, not groove.
 
Once I have the major elements arranged, I much prefer chasing groove with a real drummer and a feedback loop with at least one other musician. In my experience, drummers can lock with this kind of click, AND with tracks laid down to this kind of click, easier than others I've tried.
 
Sometimes I can point em in the right direction with a freeform hat, sometimes it gets in the way.
 
There are no perfect solutions, but you might give this a try just to see what happens.

One, two, three, four...might create a structure you, or another creative mind can add to and develop, and its going to be very difficult to do that without a rhythmic structure, even if you're in the same room, but..,
 
...think on the difference between the acoustic guitar strumming you mention, of single down strums, one, two, three, four...and alternating, one and two and three and four and...now leave one or more out, beats or ands...or take it further, and throw in a ...three and a four and a....they are whole different animals.
 
If you pick one and stick to it rigidly, then bring a drummer in, he is able to lag and or push the beat at micro intervals 
that are dwarfed by the relatively large difference between three and four, and three and a four.  When he does, (for better or worse), a live rhythm guitar is going to respond to that, in opposition, back towards rhythmic rigidity, or in support, varying the timing more yet, again for better or worse, after which, the drummer will further respond, either direction, and synergy will accelerate until it declines and the direction takes substance, or the pkayers diverge and work seperately.
 
That's why, for me, its not really music till at least one other creative mind has some input to it. (This could be the same person, on a different day and in a different headspace.)
 
Topping it off, one person's better is another's worst.  This leads me to a fundamental separation between rhythmic structure, and groove. Many stick to a simple metronome for structure, but I've noticed its easier for people I play with, me included, to start w snare and kick, probably for two reasons. One is what everybody is keying on for rhythmic foundation, and drums live in different frequency domains than the click of a metronome. Two, the envelope of a drum is longer that a click, and there's more tolerance in timing, which has both timing, and confidence, repercussions. I prefer not to...train...partners to listen for a mid and upper mid click,  then take that away and replace it with a low end kick.
 
On a side note, to me, the hats are so expressive that I like to keep them out of the equation till everybody is on the same page, structure is commonly understood, and we're past that into groove and swing. But I also don't like to get too far away from the highly transient and precise nature of the metronome either, so my click tracks reach for a balance between the two.  This works for me...today... and might easily change tomorrow, so its not even a suggestion, but instead, simply discussion, simplifying certain areas and priorities, for the purpose of exploration, rather than direction.

an observation... I prefer working with a live drummer, but when that's not happening I still prefer a click, specifically the UREI metronome click. I still have a UREI metronome in the rack, but don't use it as much as I used to.
 
There is just something very precise - to my ears anyway - about those clicks. And I think that's a big part of playing to a click... you need to really know the click sounds.

The other thing, again to me, is that playing to a click is playing to a metronome, even if there are tempo changes programmed in it is all about precision. Playing to a groove is more fluid, more musical if you will. A live drummer can react to the other players, and I can react to the live drummer. It is a lot different than using a drum library for me.

Now I am not complaining about drum libraries... I use them all the time because I can not always afford to get a drummer in - and space is cramped when I do - and so on<G>... and sometimes I want to write a very specific drum part.

But playing along with those tracks just doesn't work for me... go figure!

Forgive my dumb - what is the UREI metronome - is that  a metronome plug in?