PC Configureation, multiple HDs best setup of X3 help plz

So I have a current PC configuration of C Drive 80gb SSD and D Drive 1tb.  Couple of external usb drives for offline storage.
 
Currently my C Drive (SSD 80gb) has VST plugins and D Drive has Cakewalk Sonar X1d and all my other sample libraries and other applications (Komplete 9 Ultimate libraries, Omni, Reason refills etc.).
 
managing the 80GB ssd drive is crazy.  space is limited.
 
I bought a new PC i7 3.6ghz blah blah blah.
 
New PC configuration is C Drive 120gb SSD and D Drive 2tb. faster drives than before with more storage.  Before I install any software I am adding a E Drive 2 tb.  3 hard drives.
 
I have read in the past that 3 drives is best configuration as read/write to separate hard drive devices helps with lag, latency etc.
 
So where should I be installing software onto each drive for the best performance?  I really want to keep the SSD Drive as clean as possible so I am not managing space all the time (120gb space gets eaten up goes SOOO fast).
 
So is it:
 
C Drive Cakewalk
D Drive VST Plugins/Cakewalk project files/Appz (NI Komplete, Omni, Nexus, etc)
E Drive sample libraries (Kontakt, EastWest, Sampletank etc).
 
???  Do I need the 3rd drive, as I have lived with 2 drive for many PC Configs is 2 okay and enough?
 
I really would like to set this system up for best use once before having to change again.
 
any advice help would be greatly appreciated.
 

robert_e_bone
I used to use SSD drives, but found them to be unreliable - 2 out of 2 failed within 8 months of purchase.  (These were also pricey 512GB drives from almost 2 years ago). 

What make were these drives Bob?

To the Op, I have C drive with Sonar, D drive for projects/audio and an ssd drive for samples.

Works well for me. Hoping my SSD doesn't bite the dust like Bobs!

Here's how I'd configure the HDs:
 
C:  OS/Apps
D:  Audio files (projects)
E:  Samples
 
An SSD for the boot drive makes Windows navigation a bit "snappier".
A nicety... but not a necessity 
 
No need to go SSD for your audio drive.
SATA-III HDs are plenty fast... and offer more space/$
 
Disk-streaming samples is where SSD really shines.
At ~3 times the speed of a fast conventional HD, you can pull massive polyphony.

If you go to the Start Menu in Windows 8 and drag the Desktop tile to the upper-left most corner, that will be easy to see on start up, and once you click in there you are back to your regular desktop.
 
Then all you have to do is go on a one-time romp through All Apps and either pin the ones you really want to access regularly to either the Start Menu or to the task bar, or both, and then you will find yourself mostly working out of the desktop view, which is pretty much just like Windows 7.
 
Just a thought.  There are also quick access methods of doing things like restart and shutdown.
 
If you were planning to have to purchase Win 7 to put it on that PC, you could configure as above, then take the savings and upgrade the Melodyne to the full editor.
 
Bob Bone