Question about FX Chains in Sonar X3

Can anyone tell me if it is advantageous to run FX Chains as opposed to a group of individual audio efx from a sampling/bit rate perspective?
What I am getting at is this: if the efx are in an FX Chain, will the sample/bit rate remain in a more desirable state as opposed to going in and out of each plug-in? Or, is this not a factor at all in this case?
Thanks in advance!