Another TASCAM 16x08 here.  Great interface for me.  Doesn't have 16 line inputs though.  Even the 20x20 is split up ... or rather it will be when released.
 
 

Focusrite 18i20. Rock solid performance, great sound and fantastic customer service.

After many years using an M-Audio Firewire 1814 I recently purchased an Antelope Orion 32 (with the MP32 Mic- Pre's). I cannot say that I have mastered this thing yet, but so far it's been awesome.  Admittedly it's pretty pricey but I am loving the 32 channels of I/O!  No need to worry about linking units to expand I/O with this interface!

Love my roland octacapture , and as mentioned you can chain two together ( not done that yet ) , you can pick up these nowadays for a lot less than I paid . 
Ric
 

Using  a Focusrite Scarlett 18i8, with the extra 8 inputs via ADAT from a Behringer ADA8200.
Lexicon MX300 connected to the Scarlett via S/PDIF.
 
Had to spend a bit of time with the Scarlett MixControl software to wrap my head around all the routing possibilities - 
but everything works great!!

RME HDSP9652 (PCI) + RME ADI-8 QS interfaced via ADAT lightpipe.

RME UCX here.
Rock solid since day one, zero latency issues.
 

M-audio Delta 44.  I can't remember when I got this thing, but it is OLD and still works great.  There are no Win10 drivers for it, and probably never will be, and why I'll be staying with Win7, likely until something forces me to do otherwise. 
 
PS: Haters gotta hate.

Liquid Saffire 56 here. You may find this helpful  http://d3se566zfvnmhf.clo...affiredualuniteng0.pdf

I am kind of surprised there are not a lot of Presonus users. Makes me wonder if there may be issues with Presonus and Sonar or, if they are just not that popular?
 
Rod
I actually also have an old Presonus Firepod and I mean quite old (perhaps 10 years now) Still working fine on one of my older systems - went Focusrite when I put a new system in my studio in Cape Town a number of years back, and there was no Presonus dealer in South Africa at that time. I liked the Focusrite so much I then decided to stay with them when I upgraded here.
No issue from Presonus for me, just very happy with Focusrite
Nigel
 

MR816  as well , FYI Leonard, I am on windows 10 with no problems with the driver.

I sold my two FF800s to get an RME UFX.not question about the quality of sound and super low latency.

I had a Presonus Studiolive 2442 but sold it and recently purchased a Presonus RM16AI. For the price I can't believe what's been packed into this unit and it sounds great too. I'm interested in exploring the cohesion between the Presonus hardware and software.

All on Win 10.

2 Roland Studio Capture 1610's synched together for 32 ins and 20 outs! Love 'em!

I use two - a TC Konnek 48.  With the new FW drivers latency is below 5 ms.  I also use a TASCAM UH-7000 both connected to the 48 via Spdif/AES or just use it over USB if latency isn't an issue (10ms) or don't need the extra inputs.
 
@
PS - I had Presonus (Firestation in the dark ages and a FirePod later) and have nothing but good things to say about the hardware and company.  The TC was a step up in sound quality (esp. the preamps in those older units) and the TASCAM another step up.  But bang for buck, it is hard to beat the Pod or whatever they are calling it now.  If you don't need the extra inputs, most of the stereo hardware will allow you to do good work.

Plain and simple
 
Focusrite Scarlett 6i6 or anything FOCUSRITE!!   100% rock Solid and million times better than older interfaces.
I used to have no end of trouble with my EMU 0404 USB box.
 
Now down to 6ms and tanking along!!!
 
ATB
John