Thanks for the detailed info. I will keep a close eye on this during my test phase today and tomorrow.
I'm on the latest firmware and actually intend to stay there (fingers crossed) as MOTU introduced some nice features when you have several units network via AVB (e.g. like channel name forwarding which makes handling large setups much easier).
BTW, we might have discussed that before but does it also happen with all other USB devices unplugged except for the MOTU??? The reason I bring this up again is that I repeatedly have problems with the Roland A-Pro MIDI controller which is connected via USB. Although working perfectly by itself it has some really negative influence on other devices e.g. I could not launch USB control software of other devices while having the A-Pro on until I moved that to a different port on the main controller ... and I also remember getting crackles in the MOTU recordings due to the A-Pro being switched on and just sitting there idle. I discovered this by pure coincidence but back then it was fully reproducible. (Hence I will part with this controller pretty soon ...)