>> Still trying to find some information or recommendations on the PCI to PCIex adapters.
That's an avenue of investigation that did not occur to me. Interesting idea.
I've ordered a Scarlett 6i6 from Sweetwater. Small investment in a decent interface which will be handy for portable applications in the future, if it works out. Also has resale value. In the meantime I'll find out what kind of performance i can expect from USB2 on my current DAW.
(When I upgrade the DAW itself, i figure performance can only improve with the faster CPU, etc.)
One thing to note is that, if possible, you should use a dedicated USB2 hub for the audio interface. There's a couple of USB hub enumerators that can help map out which external USB port on the box is connected to each hub controller, USB1 or USB2, or USB3, etc.