Me, I just record my "real" gear and either commit to it at that point or re-do later if necessary.

 
Pretty much the same here. if I really like the sound I'm getting from amp/fx boxes then I reason that it should be possible to capture that tone by careful mic placement. Sometime shifting the mic by as little as an inch can make a massive difference to the recorded sound.
 
Another option to explore is running from a couple of stomp boxes into something like a Pod.

This may have been mentioned but you could split the signal before the stompbox so you have on guitar signal going to the stompbox then the amp and the other going DI into the Inst/line in input on your interface to use with sims. There are special DI splitter for guitar you can buy for this that aren't too pricey. I recently discovered I could do this with my Boss TU-2 tuner pedal which has two outputs. I'm not sure if it causes any signal reduction but it seems to sound alright. Still the splitter made specifically for this purpose are likely better and some of the ones I was looking at in the summer had a special transistor to mimic an amplifiers preamp electronics so that you get a better DI signal. The transistor lets you plug straight into a board's line input to so you can route it to wherever you want from there. Pretty cool.
 
Not sure if that's helpful for your needs though.

Beeep, in the Techniques Forum, Weekly Tips thread, Craig and czyky gave some good info on "Splitting" the signal coming out of a guitar.

One of the tips they gave was coming out of a buffered pedal such as the Boss TU-2 "Bypass" output.

They also give compelling reasons to use a simple "Y" splitter cord. Good reading.

Here is a good reasonably priced DI box:

http://www.sweetwater.com/store/detail/IMP2

There are some cheaper, and a lot more available at a much higher cost.

Grem
Beeep, in the Techniques Forum, Weekly Tips thread, Craig and czyky gave some good info on "Splitting" the signal coming out of a guitar.

One of the tips they gave was coming out of a buffered pedal such as the Boss TU-2 "Bypass" output.

They also give compelling reasons to use a simple "Y" splitter cord. Good reading.

Thanks, Grem. I hadn't noticed that thread yet. I think czyky was the one who popped into my TU-2 thread to confirm it should be useable as well as bit and a couple others. Good to see some extra confirmation/details on that little experiment. It does work quite well from the minimal experiments I have done so far. The only real problem is extra hum but I think that is due to the extra cabling (and some of my cables ain't the greatest) and my cramped room. I need to try moving some stuff around to see if I can create some more hum free zones to track in. I already created elaborate cable runs to get my patch/mic cables away from possible interference sources but as I said... small room crammed with stuff all cranking out signals of some kind or another.

I am going to try the TU2 also. Thinking of getting that Whirlwind IMP 2 so I can have a good balanced dry out.

I noticed with Single Coil pups if you face more towards the PC you'll get more hum. Same with amps. Just not as much. But I am sure you got that figured out already!! I like to move when I play so it becomes a hindrance to have to stay in a certain spot. So that's why I might end up getting the IMP 2 for the balanced out

A lot of good stuff here already, but since the question is good for thought, I thought I would through my thoughts in on the matter:
 
I send a clean guitar DI into my interface.  From there I send two outs, one to my mic'd amp and the other to the effects returning to the interface (mono and stereo, respectively).  I keep these all as three separate tracks in SONAR.  I might even through another loop from the amp signal into the effects loop for a forth, more complex tone.  After the tracks have been recorded, I can begin matching plug-ins or mixing from the three or four tracks for a big dynamic guitar sound.  Recording can be so fun some times.  Hopefully most of the time if not all the time.  I do hate running cables though.
 
Kind regards,
 
Living Room Rocker