I just wanted to add an update to this thread for the benefit of subsequent googlers who come across it.
I had an "oh sh*t" moment after reading the Syba comments, especially when fireberd posted that the Syba wouldn't connect with his Focusrite Saffire Pro 40 - because the day before reading that post I had just ordered that exact same card for use with my own Pro 40. Oh sh*t, said I. I don't visit the Computers forum for a week and this is what happens!
So when it arrived I kept muttering the mantra "please work, please work" as I installed it. The good news is it works just fine. Maybe fireberd just got a bad one.