I do not know what size rooms you have to work with, but i imagine that unless you live in a big castle or something, then you will not have the luxury of making a studio with a 2 foot gap all around it.
I built an outside studio building from scratch, and if i were to have need to build a studio room inside a normal size house room, then i would use my same methods as it did not use up more space than necessary.
I built the walls and roof with 4x2 timbers.
The outside was clad with 12.5mm OSB timber boards, and then clad with timber cladding.
The inside was clad with 12.5mm plasterboard sheets and then with another layer of 12.5mm Soundblock Plaster board sheets (twice as dense as std plasterboard)
The walls were filled with high density Rockwool 100mm thick (60kg/M2 density).
All interior gaps were sealed up with mastic.
The roof was made in a similar method but with two layers of everything and then a pitched roof on top of that with 2 layers of 11.5mm plywood separated by a layer of roofing felt, and then the top waterproofed with 2 layers of roof felt (top layer Green mineral).
The base is concrete with a Floating floor sitting on it. Made up from 50mm foam flooring sheets, then chipboard flooring sheets and a laminate floor floor for the finish.
The total thickness of the walls is 8"
I have 2x doors into the studio room, staggered at 90 degrees, forming a first entrance room where the PC is situated, and then the second door which leads into the studio room itself.
THE MAIN POINT OF ALL THIS IS:
I can play and sing at full volume, while outside no one can hear anything.
I hope this is helpful to help you decide how to make best use of your space.