I own a Presonus 16:4:2 mixer which is also my interface. When I do live show recordings (recorded onto capture which is their light weight dedicated recording software), I typically mix it down on Studio One Artist which can read the captured session directly, and I am not doing a whole lot of processing. Sometimes I can mix the tracks down using the Studiolive.
When I am creating and recording music, it is Sonar all the way. I find the MIDI more intuitive, I've build up a nice collection of synths and sampler over the years, love Perfect Space and the Pantheon, and since getting the the Expanded PC Plugins, find myself using the channel FX bins less and less. I will often just send all the midi stuff to TTS-1 while working on ideas, and then re-instrument parts and replace guitars and bass with live instruments. For me it just works.
Cheers
Grif