If you do not have
Voxengo's SPAN (free), it is worth downloading and throwing as an effect onto an audio track. This will give you a look at that noise with the guitar plugged in and the PSU disconnected. I suspect (and hope) you are seeing a nice clean spike at 50Hz without nasty harmonics.
Using just this setup (not playing), you can fiddle with the noise gate, HP filter, and notch EQ to knock that spike down and save the effect chain you make into a preset for use with other tracks in the future. A noise gate alone should take care of any harmonics, but if you have a spike, it should be below the Low E (Low E = 82.4Hz).
An instrument cable is unshielded so it will act like an antenna on you. There is not much you can do but minimize its length, but you already have a 3m cable and I would not go any shorter since it would impede using the guitar.
I also own an Epiphone 335 Dot, and that selector switch should come out of the f-hole easily...
however, if you are unfamiliar with this I would blow it off for now. The wipers inside that switch may be corroded (esp. if sat for a long time unused) which can many times be mitigated by cycling the switch rapidly several times. If the switch works in both up and down positions, but noisy in the mid, I assume the internal wipers are fine, just corroded. Try cycling that switch first and see if it helps.
Let Voxengo's SPAN guide you on what is going on with your efforts to minimize it.