From World Science, interesting stuff:
Humans may be “upside-down” with respect to jelly ancestors Feb. 22, 2013
Courtesy of the University of Vienna and World Science staff The evolutionary origin of the head is traceable to a brainless organ usually considered the “foot” of creatures related to jellyfish, scientists report.
Researchers found that the same genes that control head development in higher animals govern the development of the front end of the swimming larva, or juvenile form, of a simple, brainless sea anemone. This front end becomes the so-called “foot” of the adult animal.
In many animals, the brain is located in the head, together with sensory organs and often the mouth. But there are distantly related animals that have a nervous system, but no brain, like sea anemones and corals.
The research group, led by Fabian Rentzsch of Sars Centre in Bergen, Norway and Ulrich Technau from the University of Vienna, set out to find if one of the ends of the sea anemone corresponds to the head of higher animals. The scientists studied the function of genes that control head development in higher animals during the embryonic development of the starlet sea anemone.
“Despite looking completely different, it has become clear over the last decade that all animals have a similar repertoire of genes, including those that are required to make the head of higher animals,” said Technau.
The study is published in the journal
PLoS Biology.
When the sea anemones are in the larval, or juvenile, stage they swim and search for a suitable site to settle and metamorphosize into a form called a polyp. During this process, the front end of the larva senses the environment and attaches to the ground. The other end becomes into the “oral” side of the animal with a mouth and tentacles for bringing in food.
The researchers found that the larva’s front-end development is is governed by a hierarchy of genes, controlled by the “master control gene” called Six3/6. Notably, this gene and genes that depend on it “downstream” also play a crucial role in setting up the field for making the brain of flies, fish and men, Technau and colleagues explained. Hence, the function of the “head genes” is located at the end that corresponds to the “foot” of the adult anemone.
“The anterior end of the swimming larva carries their main sense organ, so at this stage it looks more like this might be their head,” said Rentzsch. Indeed, the “head genes” function on this side of the animals, he added, yet they are not used to form a full brain.
Sea anemones and all higher animals, including humans, are believed to share a common brainless ancestor that lived between 600 million and 700 million years ago. By revealing the function of “head genes” in the anemone, the scientists believe they now understand better how and from where the head and brain of higher animals evolved. Definitely, they said, the gene network that formed a sensory center had evolved in this common ancestor some 600 million years ago.
“Based on the appearance of the adult animals, the aboral [attaching] end of these animals has traditionally been called the foot and the upper end the head, while in fact it is basically turned upside down,” explains Technau. “Or we...” he added with a smile.