Hi Starise,
I'll give you my opinion for what it's worth. With higher gain in your sound, you're not going to notice much difference in guitars, pick-ups or the tone. Gain has a way of hiding those elements.
For example, I can play 5 different guitars in my rig right now and post the results....a few *may* hear a slight difference, the majority will hear no difference unless I use a strat or a tele. Anything with humbucks is going to be close unless you use something with a super distortion or Fernandes sustainer or something.
The same with changing pups....you'll notice differences in presence, maybe some will have more mids...less mids, 4k boost...but there will be nothing mind blowing.
Now, if you go to a clean sound or a very light gain, this is where you start to hear the true tonality within the guitar. Active pups are going to really shine here and stick out more in a good way. Passive pups will have less presence and be less expressive to touch/execution.
I remember during my "pup trial" days where I went to a music store and bought every pup they had to try out. It was amazing how close they all sounded when higher gain was used. But back that gain down, or use a clean sound and then you could hear the differences. You WILL hear differences in the higher gain, but it won't be night and day unless you are comparing say Gibson Dirty Fingers to a Seymour Duncan Custom. No comparisson....the Duncan Custom will obliterate the Gibson in the tone area whether you're using high gain, light gain or a clean sound.
Your best bet when buying guitars where you will be using them for higher gain, is to buy them for feel and playability over looking for a mind-blowing tone difference. The gain will always mask a majority of the tone. You'll hear subtle things, you'll get a little more sustain at times or hear certain frequencies accentuated, but it's never going to be a "wow" factor in my opinion and experience. Most humbuckers that come stock with any kind of rock guitar are going to have a similar output and tone with the differences being so subtle, they may not be worth talking about.
Be careful if you decide to raise the pups up super high like Zungle mentioned. Sometimes if you raise them too high, you can literally get dual tones when trying to tune as the string does something funny when too close to the pup. You can really hear the effects of this as strings get old and tuning can become a nightmare.
My rule of thumb is to chug some chords with higher gain. I raise the bass part of the pup until the notes I chug start to sound like a run on sentence without any percussive attack. When I hear that, I back the pup down until that goes away. For the high end of the pup, I fret the highest note on the neck and adjust the higher end of the pup until it gives me a nice sustain/hold without any weird artifacts. You can get away with raising this side a bit higher. By the time I get done, sometimes my high side is a little higher than my bass side. It depends on the guitar as well as how much output the pups give me in a particular area. Hope some of this helps....good luck and I love the look of that guitar! :)
-Danny