I might try to find some time and do some testing for you as I too use a Scarlett.
I didn't rely on amp sims as extensively since I got my Scarlett because I had a bunch of other options - real amps, the direct out on my Spider IV, a POD HD...
Most of my work with amp sims I tried to do using my old M-Audio Fast Track, either direct, either going through a preamp, or a combination of devices. But as far as I can recall, I wasn't happier with the Scarlett in that regard.
It always left me with the impression that the amp sim was adding a coat of distortion on top of my otherwise very, very flat and lifeless guitar track - no matter how hot the signal I fed the amp sim.
The Hi Z switch was a surprise because for the first time, it sounded as if the guitar was biting into the amp - it was not simply dressed in overdrive, it was overdriving, punching through.